Pharmacel® sMCC 90

  • Synergistic solution for formulation success
  • Silicified microcrystalline cellulose
  • Multifunctional excipient
  • Direct compression for challenging formulation

Pharmacel® sMCC 90

Pharmacel® sMCC 90, a silicified microcrystalline cellulose, developed as the synergistic solution for challenging oral solid dosage formulations. Co-processing microcrystalline cellulose with silicon dioxide increases its surface area, resulting in enhanced powder flow, superior tabletability, and improved formulation robustness.
Typical values

Density

Tapped density

470

g/l

Bulk density

310

g/l

Particle size

D10
-
35
μm
D50
-
110
μm
D90
-
270
μm
Hausner ratio
1.52
Production site
Nagpur, India
Sample size
Default
500
g

 

 

Pharmacel® sMCC 90 benefits
This new addition to our well-established excipients’ portfolio offers customers worldwide the highest quality excipients and services. Pharmacel® sMCC 90 has the following benefits compared to conventional excipients:

  • Improved tablet compression
  • Higher production speeds
  • Rapid formulation development

Improved tablet compression
Pharmacel® sMCC 90 is a highly functional excipient for direct compression processes. In comparison with conventional excipients, Pharmacel® sMCC 90 leads to lower capping of tablets at high compaction speed thereby enabling 20% harder tablets.

 

 

 

Higher production speeds
The production speed of tablets depends on the pace of several intermittent steps. Pharmacel® sMCC 90 enables higher processing speed in n multiple units of operation. Additionally, Pharmacel® sMCC 90 allows for a swift and more consistent flow from the hopper.

 

 

The flowability of Pharmacel® sMCC 90 enables consistency in tablet weight, with weight variation below 1% for 250mg placebo tablets.

Rapid formulation development

Pharmacel® sMCC 90 mitigates formulation challenges due to its improved flow and compaction compared to conventional excipients. Additionally, low lubricant and dwell-time sensitivity allow for easy-scale up. Moreover, Pharmacel® sMCC 90 reduces the number of excipients compared to regular grades and removes the need to process silica.

 

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