Pharmacel® sMCC 90

多機能・高機能添加剤

優れた圧縮性と流動性

製剤の堅牢性を確保し、スケールアップが容易

Oral Solid Dose

製品情報

Pharmacel® sMCC 90は、経口固形製剤の課題解決のために開発されたケイ化微結晶セルロースです。結晶セルロースを二酸化ケイ素と共加工することにより、表面積が増加し、粉体流動性が向上し、優れた打錠性が得られ、製剤の堅牢性が改善されます。

Pharmacel® sMCC 90のメリット

この新しい添加剤は、当社の添加剤ポートフォリオに追加され、世界中のお客様に最高品質の添加剤とサービスを提供させていただきます。Pharmacel® sMCC 90は、従来の添加剤と比較して、以下のような利点があります。

- 錠剤の圧縮性の向上

- 生産速度の向上

- 迅速な製剤開発

錠剤の圧縮性の向上

Pharmacel® sMCC 90は、直接打錠用の高機能性添加剤です。従来の添加剤と比較して、高い打錠速度でもキャッピングが少なく、錠剤硬度を20％高めることができます。

生産速度の向上

錠剤の生産速度は、断続的なステップでの速度に依存します。Pharmacel® sMCC 90は、複数の操作で、より高い処理速度を可能にします。また、Pharmacel® sMCC 90は、ホッパーからの流れをより速く、より安定させることができます。

Pharmacel® sMCC 90の流動性により、250mgプラセボ錠の重量変動が1%未満となり、錠剤重量の安定化が図られています。

迅速な製剤開発

Pharmacel® sMCC 90は、従来の添加剤と比較して、流動性と圧縮性が改善されているため、製剤化の課題を解決します。また、潤滑油や滞留時間の感度が低いため、スケールアップが容易です。さらに、Pharmacel® sMCC 90は、通常のグレードと比較して添加剤の数を減らし、シリカを加工する必要がありません。

包装形態

- 25kg PEライナー付き多層紙袋 r

- サンプルサイズ：500g

生産拠点

インドNagpur

品質保証期間

36ヶ月再試験

製品の種類: 結晶セルロース
添加剤の機能性: 結合剤, 希釈剤, 充填剤・バインダー, 崩壊剤
推奨プロセス: 直打法, ドライブレンド, 湿式造粒
剤形: カプセル剤（経口固形剤）, 口腔内崩壊錠, 錠剤, 分包品

代表的な製品データ

粒度分布(μm)

X10: 35
X10: 110
X90: 270

嵩密度(g/L)

嵩密度(g/L): 318

ハウスナー比 (-)

ハウスナー比 (-): 1.46

LOD (% w/w)

LOD (% w/w): 4.4

ドキュメンテーション

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Non dangerous substance
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BSE Statement Pharmacel®
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Residual solvent Pharmacel
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Shelf life statement Pharmacel
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Shelf life statement Pharmacel sMCC
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Re-compaction properties of lactose and mcc 表示
Roller compaction of anhydrous lactose and mcc 表示
MCC Effect of Increasing Pharmacel Concentration on the Tableting Properties of DC Diluents 表示
Impact of excipient and blend properties on feeding consistency for continuous manufacturing 表示
Choosing the optimal lactose and MCC grade for formulating moisture sensitive drugs 表示

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