Physical – Chemical Properties
Pharmacel® 112 can be characterized by its narrow bulk density specification (0.28-0.34 g/ml) and its consistent, good flow properties. Typical values for the key parameters are shown in the table below Uniform flow of the excipient is a prerequisite for consistent production. Pharmacel® 112 exhibits very consistent flow behavior when analysed using a ring shear cell tester.
Tabletability and Dwell Time
Excellent tabletability and low dwell time sensitivity of Pharmacel® 112 enables processing at low to moderate compaction forces. The low dwell time sensitivity of Pharmacel® 112 is demonstrated in the table below by the comparable tablet tensile strength at slow (50 mS) and fast (20 mS) tableting speed.
Pharmacel® and Lactose Formulations
DFE Pharma is the only global excipient company who offers both lactose and microcrystalline cellulose. The optimum tableting balance between flow and compaction can easily be achieved by combining Pharmacel® 112 with one of the direct compressible lactose grades (SuperTab®) offered by DFE Pharma achieving the perfect combination of brittle and plastic excipient behavior.
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