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Pharmacel® 112

Low moisture content (LOD Max. 1.5% w/w)

Suitable for highly moisture sensitive APIs

Highly protective packing

Oral Solid Dose

Product information

Pharmacel® 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture.

Pharmacel® 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent, diluent and/or disintegrating aid. Its low moisture content may lead to improved drug stability without compromising the performance of the final drug product.

The highly protective packaging guarantees complete protection of Pharmacel® 112 from moisture uptake over the 4 year of shelf-life.

Packaging

- 25 kg Multi-layer paper bag with PE liner

- Sample size: 500g

Production site

Cuddalore, India

Product types: Microcrystalline cellulose
Excipient functionality: Filler-binder, Diluent, Binder, Disintegrant
Recommended process: Direct compression, Dry blending
Dosage forms: Tablet, Capsule (Oral Solid Dose), Orally disintegrating tablet

Typical product data

Particle size distribution (μm)

X10: 40
X50: 90
X90: 180

Bulk density (g/L)

Bulk density (g/L): 330

Hausner ratio (-)

Hausner ratio (-): 1.39

LOD (% w/w)

LOD (% w/w): 1.3

Documentation

ALBA Pharmacel
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Oral Solid Dose Brochure View
Contaminants Statement Pharmacel
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GMO Statement Microcrystalline Cellulose
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GMP DFE Pharma India Nagpur
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Nutritional information Pharmacel
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Product Specification Pharmacel 112
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DFE Pharma Leaflet Pharmacel 112 View

Process Flow Sheet (PFS) Pharmacel® 112
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cGMP Statement
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Stability Summary Pharmacel®112
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Re-compaction properties of lactose and mcc View
Roller compaction of anhydrous lactose and mcc View
MCC Effect of Increasing Pharmacel Concentration on the Tableting Properties of DC Diluents View
Impact of excipient and blend properties on feeding consistency for continuous manufacturing View
Choosing the optimal lactose and MCC grade for formulating moisture sensitive drugs View

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