Pharmacel® 101

Pharmacel® 101 Microcrystalline cellulose (MCC) has been developed specifically as a key component for wet granulation and dry granulation formulations. DFE Pharma offers Pharmacel® 101 from two high quality production sites.
Typical values

Density

Tapped density

440

g/l

Bulk density

280

g/l

Particle size

D10
-
25
μm
D50
-
60
μm
D90
-
120
μm
Hausner ratio
1.57
Production site
Nagpur, Cuddalore, India
Sample size
Default
500
g

Consistency

Pharmacel® is industry leading with high batch-to-batch consistency on functional properties allowing you low risk during production and in your formulation development.

Pharmacel® and lactose formulations

DFE Pharma is the only global excipient manufacturer offering it’s customers both lactose and microcrystalline cellulose products for development of pharmaceutical formulations. Combination of Pharmacel® with one of the lactose grades offered by DFE Pharma provides additional benefit to formulations, by achieving the perfect combination of brittle and plastic excipient behavior.

Wet granulation

Pharmacel® 101 microcrystalline cellulose (MCC) has been developed specifically as a key component for wet granulation formulations. Using Pharmacel® 101 ensures even distribution of the granulating fluid, which in turn means uniform granulation and drying processes. Wet granulation with Pharmacel® 101 is a reliable, easily repeatable and robust process. Tablets made using Pharmacel® 101 show excellent compaction and disintegration properties.

Dry granulation

Pharmacel® 101 microcrystalline cellulose (MCC) is also an ideal excipient for use in dry granulated formulations. Ribbons do not stick to the compaction rolls during roller compaction and dry granulation can be used in formulations with a high drug dosage. For dry granulation Pharmacel® 101 opens up vital production synergies. Used with a brittle excipient, such as SuperTab® 21AN anhydrous lactose, the result is an ideal combination of high tablet strength and insensitivity to re-compaction, leading to outstandingly robust dry granulation formulations.

 

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