Lactohale® 230

ファインラクトース

不規則な形状の粒子で粉砕

製剤設計に最適な流動性と性能を実現

Inhalation

製品情報

Lactohale® 吸入ブレンド製品は、お客様の最適な粒度分布を持つ理想的な製品です。吸入用グレードの乳糖の特性は、通常、装置内の必要流量、充填プラットフォームへの必要流量、必要な薬物付着量など、さまざまなパラメータに基づいて選択されます。標準的なLactohale®グレードの包括的なラインナップは、お客様の多様なニーズをカバーするために用意されています。

DFEファーマは、吸入用乳糖ブレンド製品群でもお客様をサポートします。Lactohale® 206, Lactohale® 210, Lactohale® 220, Lactohale® 230 and Lactohale® 300のLactohale®製品群は、特に開発の初期段階にある処方担当者の方や、処方のデザイン空間を探求したい方にとって興味深いものだと信じております。

Laser Diffraction Particle Size Graphs Lactohale 230

乾燥粉末吸入製剤へのクオリティ・バイ・デザインアプローチ

Lactohale® 206 は、乳糖の微粒子を除去した粗粉砕のアルファ乳糖一水和物グレードです。この粗粉砕乳糖グレードは、良好な流動性が必要とされる用途において、基本的な乳糖として使用することができます。この粗粉砕グレードと微粉砕乳糖を混合することで、乾燥粉末吸入ブレンドの流動性と沈殿を最適化することができます。この最適化には、Lactohale® 210、Lactohale® 220、Lactohale® 230、およびLactohale® 300という異なるタイプの微粉末が利用可能です。非常に微細な乳糖グレードとのブレンドは、通常、薬剤の沈着に大きな影響を与えます。Lactohale® 210のようなやや粗い微粉末の添加は、主に粉体の凝集性に影響を与えますが、沈殿への影響は限定的です。

DFEファーマでは、Lactohale®およびRespitose®と呼ばれる、粉砕および篩過した幅広い吸入用乳糖グレードをご用意しています。お客様は通常、Lactohale® DoE製品から開発を開始し、製剤の性能を微調整するためにカスタマイズに移行することができます。密接な連携により、最適な製品性能を実現するために、流動特性を適切な微粉末の含有量に合わせることができます。その結果、特定の粒子径プロファイルを持つカスタマイズされたLactohale®グレードは、それぞれのお客様にとって唯一のものとなります。

Ph.Eur.、USP-NF、およびJPに準拠しています。

梱包形態

- 10kg カートンボードボックスNL (ALU/PE liner)

品質保証期間

3年

生産地

オランダBorculo

製品の種類: 粉砕乳糖
添加剤の機能性: キャリア
剤形: 吸入

代表的な製品データ

粒度分布(μm)

D10: 1.4
D50: 8.4
D90: 23

嵩密度(g/L)

嵩密度(g/L): 310

タップ密度 (g/L)

タップ密度 (g/L): 500

Carrの流動性指数(-)

Carrの流動性指数(-): > 25

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Absence of Melamine Lactose
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Residual solvent lactose
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Shelf life statement lactose
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Particle size measurement of lactose for dry powder inhalers 表示
The influence of lactose particle size on DPI performance 表示
Designing inhalation grade lactose 表示
Exploring the design space for dry powder inhalers 表示
Effect of Lactose Processing on Dry Powder Inhaler Dispersion 表示
Different Types of Lactose Fines have an impact on different dry powder inhalers properties 表示
Effect of Loaded Dose on Delivered Dose in DPI 表示
Measurement of Lactose from DPI in Impactors 表示

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