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Lactohale® 300

微粉化

极细乳糖

优化处方流动性和性能表现的理想辅料

吸入制剂

Lactohale® 300是一种极细的微粉化乳糖，D50值低于5 μm。LH300可用于干粉吸入剂，以提高药物沉积率。可通过几种方式引入细颗粒来提高药物沉积率。此外，还可通过将Lactohale® 300与严格选择的粗乳糖混合，开发特定的乳糖混合物实现您的目标产品特性。

Laser Diffraction Particle Size Graph Lactohale 300

提高药物沉积率

在DPI处方中加入细颗粒……

...促使药物占据乳糖载体表面的较低能量位点，导致较低的药物-载体粘附并提高沉积率，而细颗粒乳糖将占据高能量“活性位点”。

Lucas et al.(1998) Pharmaceutical Research 15: 562 - 569.

……帮助药物-微粒团聚体的形成。与单个药物颗粒相比，团聚体面临的拖曳力更大，因此极大增强了与载体的分离。

Lucas et al.(1998) Pharmaceutical Research 15: 562 - 569./Louey et al.(20 02) Pharmaceutical Research 19: 1524 - 1531.

……在混合过程中避免药物受到高压力的作用，使得药物与载体之间的粘附力减小，从而提高沉积率。

Dickhoff et al.( 2006) International Journal of Pharmaceutics 327; 17-25.

……增加粉粒物料的抗张强度，因此最小流化能量也增加了。这导致粉粒物料在初始破裂过程中形成更大的团聚体，进而更容易分散，使得细颗粒的占比增加。

Shur et al.(2008) Pharmaceutical Research 25: 1631 - 1640.

符合欧洲药典、美国药典-美国国家处方集和日本药典的要求。

包装

- 12.5 kg纸板箱（铝箔内衬袋）

有效期

12个月

产地

荷兰Borculo

: 微粉化乳糖
辅料功能: 载体
剂型: 剂型

典型产品数据

粒度分布（μm）

D50: 5
D90: 10

堆密度（g/L）

堆密度（g/L）: 260

振实密度 (g/L)

振实密度 (g/L): 520

卡尔指数（-）

卡尔指数（-）: > 25

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Designing inhalation grade lactose 查看
Exploring the design space for dry powder inhalers 查看
Effect of Lactose Processing on Dry Powder Inhaler Dispersion 查看
Different Types of Lactose Fines have an impact on different dry powder inhalers properties 查看
Effect of Loaded Dose on Delivered Dose in DPI 查看
Measurement of Lactose from DPI in Impactors 查看

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