Lactohale® 201

ファインラクトース

不規則な形状の粒子で粉砕

製剤設計に最適な流動性と性能を実現

Inhalation

製品情報

粉砕された吸入乳糖は、不規則な形状の粒子と凝集流動性を持つ、安定性の高い結晶性乳糖です。乳糖は機械的に粉砕され、様々な粒子径になります。これにより、製薬企業は製剤のニーズに合った最適なグレードを選択することができます。

製造中の厳格で一貫した粒子径管理、および最新の粒子径測定技術の組み合わせが、弊社の吸入用粉砕グレードの成功の基礎を形成しています。DFEファーマでは、Lactohale®とRespitose®が吸入用乳糖の粉砕グレードのブランドとなっています。

Laser Diffraction Particle Size Graph Lactohale 201

粒子径と流動性

Lactohale® および Respitose® 粉砕乳糖グレードは、粒子径が制御された不規則な形状の粒子で構成されています。粉砕乳糖は通常、幅広い粒度分布を持ち、中央粒径は篩過乳糖よりも小さくなっています。その微細な性質と比較的高い表面積により、粉砕乳糖の流動性は凝集性から非常に凝集性の高いものに分類されます。粉砕乳糖は、例えば、膜充填技術における凝集性や、カプセル充填技術における栓の形成を可能にするために一般的に使用されています。

異なる乳糖グレードを組み合わせて使用することで、製剤の流動性と微粉含有量を最適な製品性能に調整することができます。DFEファーマでは、Lactohale®およびRespitose®と呼ばれる、粉砕および篩過された幅広い吸入用乳糖グレードをご用意しています。また、カスタマイズも可能です。

Ph.Eur.、USP-NFおよびJPに準拠しています。

梱包形態

- 20kgカードボックスNL（アルミ・PEライナー付）

品質保証期間

3年

生産地

オランダBorculo

製品の種類: 粉砕乳糖
添加剤の機能性: キャリア
剤形: 吸入

代表的な製品データ

粒度分布(μm)

D10: 3.3
D50: 22
D90: 56

嵩密度(g/L)

嵩密度(g/L): 500

タップ密度 (g/L)

タップ密度 (g/L): 700

Carrの流動性指数(-)

Carrの流動性指数(-): >25

ドキュメンテーション

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Residual solvent lactose
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Shelf life statement lactose
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Please follow the instructions to see our documents:
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2. The document will be displayed in your web browser. If a login window to MasterControl appears, please use an incognito/private window, or clear the cache of your browser.
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The PDFs are technically modified by DFE Pharma’s controlled documentation system. Please follow the instructions to download and save our documents:
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Particle size measurement of lactose for dry powder inhalers 表示
The influence of lactose particle size on DPI performance 表示
Designing inhalation grade lactose 表示
Exploring the design space for dry powder inhalers 表示
Effect of Lactose Processing on Dry Powder Inhaler Dispersion 表示
Different Types of Lactose Fines have an impact on different dry powder inhalers properties 表示
Effect of Loaded Dose on Delivered Dose in DPI 表示
Measurement of Lactose from DPI in Impactors 表示

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