Lactohale® 100

結晶性篩過乳糖

トマホーク型粒子

高い流動性

Inhalation

製品情報

篩過乳糖は、トマホーク型の粒子で、表面が滑らかで流動性の良い結晶性乳糖です。篩い分けにより様々な粒子径を実現し、お客様の製剤ニーズに合わせた最適なグレードを選択することができます。

製造工程における厳格で一貫した粒子径管理、および最新の粒子径測定技術が、弊社の吸入用ふるい分けグレードの成功の基盤となっています。DFEファーマでは、Lactohale®とRespitose®が、製剤のデザインスペースを篩い分ける吸入用乳糖グレードのブランドとなっています。

Laser Diffraction Particle Size Graph Lactohale 100

粒子径と流動性

Lactohale®およびRespitose®の篩過乳糖グレードは、粒子径が制御された医薬用α-乳糖一水和物です。粒度分布は一般的に比較的狭く、中央粒径は一般的に粉砕乳糖よりも大きくなっています。Carrの指数(Carr's Index)は、十分から良い流動性を示しています。したがって、篩過乳糖は流動性が重要視される製剤に有効です。このタイプの乳糖は、例えば、リザーバー装置で一般的に使用されています。良好な流動性と粉体層の安定した密度により、投与ユニットは常に一定量の粉体で満たされています。篩過糖は、粉体流動性が要求される他のプラットフォーム、例えばドージングディスクカプセル充填技術においても推奨されます。粉砕された乳糖を使用することで、より高い凝集力を得ることができます。

吸入用乳糖の粒子径は、装置や充填プラットフォームに求められる流動性に加えて、一般的に薬剤の沈着量を最適化するために選択されます。異なるラクトースグレードを組み合わせて使用することで、製剤の流動性と微粉含有量を最適な製品性能へと導くことができます。DFEファーマでは、Lactohale®およびRespitose®と呼ばれる、粉砕および篩過糖の幅広いグレードをご用意しています。当社の全製品をご覧いただき、どのグレードがお客様の製剤ニーズに合っているかをご確認ください。

Ph.Eur.、USP-NFおよびJPに準拠しています。

梱包形態

- 20kg カードボードボックスNL（ALU/PEライナー付き）

品質保証期間

3年

生産地

オランダBorculo

製品の種類: 篩過乳糖
添加剤の機能性: キャリア
剤形: 吸入

代表的な製品データ

粒度分布(μm)

D10: 58
D50: 132
D90: 214

嵩密度(g/L)

嵩密度(g/L): 840

タップ密度 (g/L)

タップ密度 (g/L): 960

Carrの流動性指数(-)

Carrの流動性指数(-): 12

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Residual solvent lactose
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Please follow the instructions to see our documents:
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The PDFs are technically modified by DFE Pharma’s controlled documentation system. Please follow the instructions to download and save our documents:
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Shelf life statement lactose
IMPORTANT: PLEASE READ BEFORE VIEWING OR DOWLOADING DOCUMENTS
View documents

Please follow the instructions to see our documents:
1. Click on "Download document"
2. The document will be displayed in your web browser. If a login window to MasterControl appears, please use an incognito/private window, or clear the cache of your browser.
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The PDFs are technically modified by DFE Pharma’s controlled documentation system. Please follow the instructions to download and save our documents:
1. Click on "Download document"
2. The document will open in Master Control, in a window of your browser. Click on Download>PDF
3. This will open a new browser window with an empty document. Click on "Save". The document will be saved to your computer.
4. This will open a new browser window with an empty document. Click on "Save". The document will be saved to your computer.
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Particle size measurement of lactose for dry powder inhalers 表示
The influence of lactose particle size on DPI performance 表示
Designing inhalation grade lactose 表示
Exploring the design space for dry powder inhalers 表示
Effect of Lactose Processing on Dry Powder Inhaler Dispersion 表示
Different Types of Lactose Fines have an impact on different dry powder inhalers properties 表示
Effect of Loaded Dose on Delivered Dose in DPI 表示
Measurement of Lactose from DPI in Impactors 表示

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