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Microcrystalline Cellulose (MCC)

Microcrystalline Cellulose is a purified, partly depolymerised cellulose with shorter, crystalline polymer chains. Its strong binding performance make MCC one of the most commonly used fillers and binders in drug formulations, together with Lactose. The product is manufactured by controlled partial hydrolysis of high purity wood pulp, followed by purification and drying.

MCC

Excipients - Oral Solid Dose - MCC

Pharmacel® 101

  • Microcrystalline cellulose
  • Highly consistent excipient
  • Strong binder for wet and dry granulation
D10 D50 D90
Particle size 25 60 120
Sample size 500
Hausner ratio 1,57

Pharmacel® 102

  • Microcrystalline cellulose
  • Highly consistent excipient
  • Improved flow suitable for direct compression
D10 D50 D90
Particle size 40 90 180
Sample size 500
Hausner ratio 1,42

Pharmacel® 112

  • Microcrystalline cellulose
  • Highly consistent excipient
  • Suitable for water sensitive drugs
D10 D50 D90
Particle size 40 90 180
Sample size 500
Hausner ratio 1,39

For formulation development, Pharmacel® can be applied in a wide variety of oral solid dosage forms, including tablets, capsules, sachets, pellets and others. MCC is widely used in diverse pharmaceutical processes, like wet granulation, dry granulation or direct compression. MCC grades with low moisture-content are especially useful for application with moisture sensitive APIs. Pharmacel® has high compactability properties, meaning that strong tablets can be made at low forces. These low forces can increase life of tooling during tableting step in production, even when the proportion of active ingredient within a tablet is high. In addition, tablets containing MCC, can be made to disintegrate readily when a superdisintegrant, such as Primojel® or Primellose® of DFE Pharma, is used, thus maximizing the potential for drug bioavailability. Combined together with various directly compressible lactose (DCL) grades (granulated, anhydrous, spray dried), MCC exhibits improved functional properties which can be useful for direct compression applications.

Pharmacel® product offering

DFE Pharma currently offers three grades of microcrystalline cellulose:
  1. Pharmacel® 101
  2. Pharmacel® 102
  3. Pharmacel® 112
These grades are ideally suited to be used in the majority of tablet and capsule formulations processed by direct compression, capsule filling, wet granulation, dry granulation or extrusion-spheronisation. While Pharmacel® 101 is mainly applied in wet granulation and extrusion-spheronisation, Pharmacel® 102 and Pharmacel® 112 possess excellent properties for use in direct compression processes. Pharmacel® 112 is recommended for application in formulations with moisture sensitive drugs, due to its low moisture content (LOD < 1.5%).