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Offices and distrubutors



Offices and distrubutors

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Oral solid dosage

Most medicines, from over the counter treatments to prescription drugs, are taken by mouth in the form of tablets and capsules. Oral medicines are convenient, flexible and cost-effective. They can be produced in large numbers very fast (production rates of 1 million per hour can be achieved). Variants that are precisely suited to individual preferences and needs can easily be developed.


Direct compression

Direct compression is the simplest form of oral dosage production as it contains the fewest process stages, leading to a shorter process cycle and faster production times.

Dry granulation 

Dry granulation is a simple and low cost method, once extremely common and again becoming more popular because of its simplicity and cost efficiency. Dry Granulation helps to increase the size of granules within powders, making it easier to form them into tablets or capsules. It also leads to dense and stable formulations for use in filling capsules.

Wet granulation

This is perhaps the most popular method for tablet production because it can be applied to almost any dosage of any drug. Wet granulation of powders improves flow and compactability of the compression mix, and this is the key to its popularity.

Extrusion spheronisation 

Extrusion spheronisation is similar in almost every respect to Wet Granulation, following similar process stages. The difference are the extra stages for shaping the processed materials, typically for use in capsules that deliver active ingredients on a timed basis.

Capsule filling

Hard gelatin capsules are a common oral solid dosage for immediate release formulations. Compared to tablets they are easy to formulate and manufacture, formulations can be developed with minimal amounts of active pharmaceutical ingredient (API) and they are easily blinded for clinical trial purposes. Additionally they provide a ready means of identification through the choice of capsule shell colour and printing, and they are patient friendly being easy to swallow and providing taste masking for unpleasant actives.

Dosage options

Patients can now choose between orally disintegrating tablets, timed release capsules and pills of different shapes, sizes and flavours. The range and variety of available solid dose options makes it possible to respond rapidly and creatively to changing user preferences and market needs.

Role of excipients

Both the efficiency of production and effectiveness of drug delivery depend on the excipients used to mix with the active ingredients. Not only must the blend of active ingredients and excipients deliver the treatment exactly as planned and predicted, it must also compress into the right shape and size, forming pills, tablets and capsules that are fit for purpose and can be produced efficiently.

Technical options

Different techniques are used to form an effective compression mix that, after processing, will provide the predicted performance in terms of flow and release of active ingredients. Each of the available techniques has advantages and disadvantages, related to number of processes, cost of materials and resources, speed and, above all, the performance characteristics you wish to achieve. 

Key considerations

To make valid comparisons and ensure best possible decision-making, a number of different factors must be taken into consideration. These include:

There are a number of moving parts in making these calculations, and the outcomes will vary depending on many different factors. To start a dialogue with our technical experts and ensure best possible decision-making make direct contact today.